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Literature summary for 3.4.22.62 extracted from
- Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization (1998), Mol. Cell, 1, 949-957.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | Apaf-1-mediated processing of procaspase-9 occurs at Asp315 by an intrinsic autocatalytic activity of procaspase-9 itself. Apaf-1 can form oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-caspase-3 + H2O | - |
Homo sapiens | caspase-3 + ? | - |
? |  |
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