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Literature summary for 3.4.22.62 extracted from

  • Li, P.; Nijhawan, D.; Budihardjo, I.; Srinivasula, S.M.; Ahman, M.; Alnemric, E.S.; Wang, X.
    Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade (1997), Cell, 91, 479-489.
    View publication on PubMed
Search for more literature for 3.4.22.62

Activating Compound

Activating Compound Comment Organism Structure
APAF-1 caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-VAD-fluoromethylketone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-caspase-3 + H2O Homo sapiens activated caspase-9 cleaves and activates caspase-3 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-caspase-3 + H2O activated caspase-9 cleaves and activates caspase-3 Homo sapiens ?
-
 ?