Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.61 extracted from

  • Beaudouin, J.; Liesche, C.; Aschenbrenner, S.; Hoerner, M.; Eils, R.
    Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis (2013), Cell Death Differ., 20, 599-610.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.61

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
plasma membrane caspase-8 is significantly more active at the plasma membrane than within the cytosol upon CD95 activation Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Bid peptide + H2O Homo sapiens
-
 ?
-
 ?
procaspase-3 + H2O Homo sapiens
-
 caspase-3 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bid peptide + H2O
-
 Homo sapiens ?
-
 ?
additional information caspase-8 very weakly cleaves nuclear export signal-DEVDR Homo sapiens ?
-
 ?
nuclear export signal-LQTDG + H2O
-
 Homo sapiens ?
-
 ?
procaspase-3 + H2O
-
 Homo sapiens caspase-3 + ?
-
 ?

Synonyms

Synonyms Comment Organism
Casp8
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function targeting of caspase-8 substrates to the plasma membrane accelerates apoptosis Homo sapiens