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Literature summary for 3.4.22.61 extracted from

  • Guicciardi, M.E.; Mott, J.L.; Bronk, S.F.; Kurita, S.; Fingas, C.D.; Gores, G.J.
    Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis (2011), Exp. Cell Res., 317, 107-116.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.61

Protein Variants

Protein Variants Comment Organism
additional information short hairpin RNA knockdown of cIAP-1, cIAP-2, XIAP, and caspase 8 using a lentiviral vector in HuH-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Q-VD-OPH pan-caspase inhibitor Homo sapiens
Z-IETD-fluoromethylketone caspase 8 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cellular inhibitor of apoptosis 1 + H2O Homo sapiens i.e. cIAP-1, TRAIL-induced degradation of cIAP-1 requires caspase 8 activity, and it is, at least in part, due to direct cleavage of cIAP-1 by caspase 8 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14790
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cholangiocarcinoma cell
-
 Homo sapiens
-
HEP-3B cell
-
 Homo sapiens
-
hepatocellular carcinoma cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
Mz-ChA-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cellular inhibitor of apoptosis 1 + H2O i.e. cIAP-1, TRAIL-induced degradation of cIAP-1 requires caspase 8 activity, and it is, at least in part, due to direct cleavage of cIAP-1 by caspase 8 Homo sapiens ?
-
 ?
cellular inhibitor of apoptosis 1 + H2O i.e. cIAP-1, degradation. No activity with cIAP-2. In vitro substrate is recombinant human cIAP-1 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
caspase 8
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens tumor necrosis factor–related apoptosis-inducing ligand, TRAIL, signaling induces caspase 8 up

General Information

General Information Comment Organism
malfunction caspase 8 knockdown stabilizes both cellular inhibitor of apoptosis 1, cIAP-1, and X-linked IAP, XIAP Homo sapiens
physiological function Tumor necrosis factor–related apoptosis-inducing ligand, TRAIL, induces degradation of cellular inhibitor of apoptosis 1, cIAP-1, requiring caspase 8 activity, for, at least in part, direct cleavage of cIAP-1 by caspase 8. Cellular depletion of cIAP-1 enhances the efficiency of TRAIL-mediated apoptosis. cIAP-1 and cIAP-2 are responsible for Lys-63 polyubiquitination of RIP1 in cancer cells, which, in turn, results in activation of NF-kappaBmediated survival signals Homo sapiens