Literature summary for 3.4.22.61 extracted from

Chen, S.C.; Chen, C.H.; Tioh, Y.L.; Zhong, P.Y.; Lin, Y.S.; Chye, S.M.
Para-phenylenediamine induced DNA damage and apoptosis through oxidative stress and enhanced caspase-8 and -9 activities in Mardin-Darby canine kidney cells (2010), Toxicol. In Vitro, 24, 1197-1202.

Search for more literature for 3.4.22.61

Inhibitors

Inhibitors	Comment	Organism	Structure
benzyloxycarbonyl-IETD-fluoromethylketone	caspase-8 inhibitor	Canis lupus familiaris

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MDCK cell	-	Canis lupus familiaris	-

Expression

Organism	Comment	Expression
Canis lupus familiaris	0.0375 mg/ml para-phenylenediamine enhances caspase-8 activity in Mardin-Darby canine kidney cells (slight increase of activity after 3 h of treatment and significant increase after 6 h of treatment)	up

General Information

General Information	Comment	Organism
physiological function	apoptosis is mediated with caspase-8 activation	Canis lupus familiaris

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Release 2023.1 (January 2023)