Literature summary for 3.4.22.61 extracted from

Camina-Tato, M.; Fernandez, M.; Morcillo-Suarez, C.; Navarro, A.; Julia, E.; Edo, M.C.; Montalban, X.; Comabella, M.
Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis (2010), J. Neuroimmunol., 222, 70-75.

Search for more literature for 3.4.22.61

Application

Application	Comment	Organism
medicine	CASP8 is a candidate gene for multiple sclerosis risk. CASP8 polymorphisms are associated with increased risk for disease susceptibility in primary progressive multiple sclerosis patients and act as genetic modifiers of the progression of multiple sclerosis in patients with this clinical form	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
Casp8	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	a significant downregulation in CASP8 expression is observed after cell activation in multiple sclerosis patients homozygotes for the protective (ACT/ACT) and risk haplotypes (GCA/GCA)	down

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)