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BRENDA support

Literature summary for 3.4.22.61 extracted from

  • Binet, F.; Chiasson, S.; Girard, D.
    Arsenic trioxide induces endoplasmic reticulum stress-related events in neutrophils (2010), Int. Immunopharmacol., 10, 508-512.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-IETD-fluoromethylketone
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-4 activation requires the action of upstream initiator components such as caspase-8 ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-4 activation requires the action of upstream initiator components such as caspase-8 Homo sapiens ?
-
?

Expression

Organism Comment Expression
Homo sapiens caspase-8 is activated by arsenic trioxide during neutrophil apoptosis, after 3 h a slight caspase-8 activity is observed only in arsenic trioxide-induced neutrophils up