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Literature summary for 3.4.22.61 extracted from

  • Garcia, S.; Mera, A.; Gomez-Reino, J.J.; Conde, C.
    Poly(ADP-ribose) polymerase suppression protects rheumatoid synovial fibroblasts from Fas-induced apoptosis (2009), Rheumatology, 48, 483-489.
    View publication on PubMed
Search for more literature for 3.4.22.61

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis of caspase-8 in absence and presence of poly(ADP-ribose) polymerase 1, PARP-1, expression, the caspase-8 expression is not influenced Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information poly(ADP-ribose) polymerase 1, PARP-1, suppression does not affect procaspase-8 expression, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Bid protein + H2O Homo sapiens i.e. BH3 interacting domain death agonist protein cleaved Bid protein
-
 ?
additional information Homo sapiens Fas-associated death domain-like IL-1beta-converting enzyme inhibitory protein, c-FLIP, can suppress Fas-mediated apoptosis by inhibition of caspase-8 activation. Caspase-8 is active via the death receptor-dependent pathway, or extrinsic pathway, complex formation and mechanism, overview ?
-
 ?
procaspase-3 + H2O Homo sapiens caspase-8 induces apoptosis by directly activating caspase-3, which in turn causes the characteristic features of apoptosis, including DNA fragmentation and cell death ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast rheumatoid synovial Homo sapiens
-
additional information constitutive pro-caspase-8 protein expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bid protein + H2O i.e. BH3 interacting domain death agonist protein Homo sapiens cleaved Bid protein
-
 ?
additional information Fas-associated death domain-like IL-1beta-converting enzyme inhibitory protein, c-FLIP, can suppress Fas-mediated apoptosis by inhibition of caspase-8 activation. Caspase-8 is active via the death receptor-dependent pathway, or extrinsic pathway, complex formation and mechanism, overview Homo sapiens ?
-
 ?
procaspase-3 + H2O
-
 Homo sapiens ?
-
 ?
procaspase-3 + H2O caspase-8 induces apoptosis by directly activating caspase-3, which in turn causes the characteristic features of apoptosis, including DNA fragmentation and cell death Homo sapiens ?
-
 ?