Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | irradiation induces TNF-alpha-mediated activation of caspase-8, and apoptosis in hepatocytes. Apoptosis induction is prevented by IkappaB antisense oligonucleotides mediated by suppression of caspases-9 and -3 activation but not of caspase-8 activation, overview | Rattus norvegicus | |
TNF-alpha/irradiation | leads to an increase of caspase-8 activity up to 3.2fold within 24 h and up to 4.4fold within 48 h after irradiation, administration of TNF-alpha to non-irradiated hepatocytes does not lead to an increased activity of caspase-8 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | co-localization with Fas death domain, FADD | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis additionally requires changes upstream of caspase-8 activation, regulation of caspase-8 and apoptosis in hepatocytes, overview | ? | - |
? | |
procaspase-3 + H2O | Rattus norvegicus | direct activation by caspase-8 in type I cells | active caspase-3 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | upon co-localization with Fas death domain, FADD, high, localized concentrations of procaspase-8 undergo autoproteolytic cleavage, releasing activated caspase-8 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
additional information | type I cells generate high levels of caspase-8 | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis additionally requires changes upstream of caspase-8 activation, regulation of caspase-8 and apoptosis in hepatocytes, overview | Rattus norvegicus | ? | - |
? | |
procaspase-3 + H2O | direct activation by caspase-8 in type I cells | Rattus norvegicus | active caspase-3 + ? | - |
? | |
procaspase-3 + H2O | activation by caspase-8 | Rattus norvegicus | active caspase-3 + ? | - |
? |