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Literature summary for 3.4.22.61 extracted from

  • Guerleyen, H.; Christiansen, H.; Tello, K.; Dudas, J.; Hermann, R.M.; Rave-Fraenk, M.; Hess, C.F.; Ramadori, G.; Saile, B.
    Irradiation leads to sensitization of hepatocytes to TNF-alpha-mediated apoptosis by upregulation of IkappaB expression (2009), Radiat. Environ. Biophys., 48, 85-94.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information irradiation induces TNF-alpha-mediated activation of caspase-8, and apoptosis in hepatocytes. Apoptosis induction is prevented by IkappaB antisense oligonucleotides mediated by suppression of caspases-9 and -3 activation but not of caspase-8 activation, overview Rattus norvegicus
TNF-alpha/irradiation leads to an increase of caspase-8 activity up to 3.2fold within 24 h and up to 4.4fold within 48 h after irradiation, administration of TNF-alpha to non-irradiated hepatocytes does not lead to an increased activity of caspase-8 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information co-localization with Fas death domain, FADD Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis additionally requires changes upstream of caspase-8 activation, regulation of caspase-8 and apoptosis in hepatocytes, overview ?
-
?
procaspase-3 + H2O Rattus norvegicus direct activation by caspase-8 in type I cells active caspase-3 + ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification upon co-localization with Fas death domain, FADD, high, localized concentrations of procaspase-8 undergo autoproteolytic cleavage, releasing activated caspase-8 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
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additional information type I cells generate high levels of caspase-8 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis additionally requires changes upstream of caspase-8 activation, regulation of caspase-8 and apoptosis in hepatocytes, overview Rattus norvegicus ?
-
?
procaspase-3 + H2O direct activation by caspase-8 in type I cells Rattus norvegicus active caspase-3 + ?
-
?
procaspase-3 + H2O activation by caspase-8 Rattus norvegicus active caspase-3 + ?
-
?