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Literature summary for 3.4.22.61 extracted from

  • An, J.; Li, P.; Li, J.; Dietz, R.; Donath, S.
    ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity (2009), J. Mol. Med., 87, 401-410.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus caspase-8 is involved in apoptosis, but does not require caspase recruitment domain, ARC, which prevents Bax translocation to the mitochondrium and thereby blocks the activation of the mitochondrial apoptotic death pathway in a t-Bid and caspase-8-independent manner, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 2-days-old Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte neonatal Rattus norvegicus
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heart
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-8 is involved in apoptosis, but does not require caspase recruitment domain, ARC, which prevents Bax translocation to the mitochondrium and thereby blocks the activation of the mitochondrial apoptotic death pathway in a t-Bid and caspase-8-independent manner, overview Rattus norvegicus ?
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 ?