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Literature summary for 3.4.22.61 extracted from

  • Cardenas, M.G.; Zotta, E.; Marder, M.; Roguin, L.P.
    In vitro induction of apoptosis and in vivo effects of a flavone nitroderivative in murine mammary adenocarcinoma cells (2009), Int. J. Cancer, 125, 222-228.
    View publication on PubMed
Search for more literature for 3.4.22.61

Inhibitors

Inhibitors Comment Organism Structure
2'-nitroflavone inhibits caspases and tumor cell growth in diverse tissues, overview Mus musculus
N-carbobenzyloxy-Ile-Glu(OMe)-Thr-Asp(OMe) fluoromethyl ketone caspase-8 inhibition inhibits apoptosis Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus apoptotic cell deathin LM3 cells is characterized by the activation of caspase-8, -9 and -3, by an increment in the expression levels of the proapoptotic protein Bax and by the release of cytochrome c to cytosol ?
-
 ?
additional information Mus musculus BALB/c apoptotic cell deathin LM3 cells is characterized by the activation of caspase-8, -9 and -3, by an increment in the expression levels of the proapoptotic protein Bax and by the release of cytochrome c to cytosol ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Balb/c mice
-
Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
LM3 cell
-
 Mus musculus
-
mammary adenocarcinoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-IETD-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Ac-IETD + 7-amino-4-methylcoumarin
-
 ?
Ac-IETD-7-amido-4-methylcoumarin + H2O
-
 Mus musculus BALB/c Ac-IETD + 7-amino-4-methylcoumarin
-
 ?
additional information apoptotic cell deathin LM3 cells is characterized by the activation of caspase-8, -9 and -3, by an increment in the expression levels of the proapoptotic protein Bax and by the release of cytochrome c to cytosol Mus musculus ?
-
 ?
additional information apoptotic cell deathin LM3 cells is characterized by the activation of caspase-8, -9 and -3, by an increment in the expression levels of the proapoptotic protein Bax and by the release of cytochrome c to cytosol Mus musculus BALB/c ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus