Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | caspase-8 is induced in brain by cerebral ischemia. Upon activation, the cytoplasmic adaptor protein Fas-associated death domain associates with the death domain of Fas, followed by recruitment and activation of caspase-8 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | caspase-8 is involved in apoptosis, ischemia upregulates cytoplasmic adaptor protein Fas-associated Fas and Fas-associated death domain, FADD, expression, and increases caspase-8 and -3 activities in ovariectomy female mouse cortex, which are significantly attenuated by estradiol | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
cerebral cortex | ipsilateral side | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IETD-7-amido-4-trifluoromethylcoumarin + H2O | a specific caspase-8 substrate | Mus musculus | IETD + 7-amino-4-trifluoromethylcoumarin | - |
? | |
additional information | caspase-8 is involved in apoptosis, ischemia upregulates cytoplasmic adaptor protein Fas-associated Fas and Fas-associated death domain, FADD, expression, and increases caspase-8 and -3 activities in ovariectomy female mouse cortex, which are significantly attenuated by estradiol | Mus musculus | ? | - |
? |