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Literature summary for 3.4.22.61 extracted from

  • Inoue, S.; Browne, G.; Melino, G.; Cohen, G.M.
    Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway (2009), Cell Death Differ., 16, 1053-1061.
    View publication on PubMed
Search for more literature for 3.4.22.61

Activating Compound

Activating Compound Comment Organism Structure
additional information TNF-related apoptosis-inducing ligand and etoposide induce caspase-8 activation, which is inhibited by caspase inhibitor N-carbobenzyloxy-VAD-fluoromethyl ketone, but not by M-791 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-carbobenzyloxy-VAD-fluoromethyl ketone
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspases are a family of aspartate-specific cysteine proteases responsible for the biochemical and morphological changes that occur during the execution phase of apoptosis, model of the intrinsic pathway: caspase-9, the apical caspase, directly processes and activates the effector caspases, caspase-3 and -7, and then active caspase-3, but not caspase-7, processes caspase-2 and -6, and subsequently the activated caspase-6 processes caspase-8 and -10. Caspase-9 but not -8 is required for etoposide-induced processing of caspase-2 and -6. Caspase processing pathways and regulation, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-8 is cleaved in the cytoplasm by active caspase-6 and also by active caspase-3. After exposure to etoposide, caspase-8 is processed to its p43/41 forms, which arise following cleavage between the large and small subunits this processing is almost completely inhibited by N-carbobenzyloxy-VAD-fluoromethyl ketone even the lowest concentration used, whereas the lowest concentration of M-791 causes a partial inhibition of the processing of caspase-8, this is not substantially increased by higher M-791 concentrations Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
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MCF-7 cell
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspases are a family of aspartate-specific cysteine proteases responsible for the biochemical and morphological changes that occur during the execution phase of apoptosis, model of the intrinsic pathway: caspase-9, the apical caspase, directly processes and activates the effector caspases, caspase-3 and -7, and then active caspase-3, but not caspase-7, processes caspase-2 and -6, and subsequently the activated caspase-6 processes caspase-8 and -10. Caspase-9 but not -8 is required for etoposide-induced processing of caspase-2 and -6. Caspase processing pathways and regulation, overview Homo sapiens ?
-
 ?