Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | rosiglitazone, i.e. BRL, induces procaspase-8 cleavage and activation to caspase-8 leading to apoptosis in breast cancer cells. Rosiglitazone transactivates the FasL promoter gene in a peroxisome proliferator-activated receptor gamma PPARgamma-dependent manner | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | Fas ligand, a type II transmembrane protein expressed on the surface of cells, induces apoptotic cell death by binding to its receptor Fas, resulting in recruitment of the Fas-associated death domain protein and caspase 8 zymogens to the receptor and the formation of the death-inducing signalling complex, after which the caspases cascade can be activated. Defects in the Fas/FasL apoptotic signalling pathway provide a survival advantage to cancer cells and may be implicated in tumorigenesis | ? | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procaspase-8 is cleaved to active caspase-8 and an 11-kDa fragment | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Fas ligand, a type II transmembrane protein expressed on the surface of cells, induces apoptotic cell death by binding to its receptor Fas, resulting in recruitment of the Fas-associated death domain protein and caspase 8 zymogens to the receptor and the formation of the death-inducing signalling complex, after which the caspases cascade can be activated. Defects in the Fas/FasL apoptotic signalling pathway provide a survival advantage to cancer cells and may be implicated in tumorigenesis | Homo sapiens | ? | - |
? |