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Literature summary for 3.4.22.61 extracted from

  • Balsas, P.; Lopez-Royuela, N.; Galan-Malo, P.; Anel, A.; Marzo, I.; Naval, J.
    Cooperation between Apo2L/TRAIL and bortezomib in multiple myeloma apoptosis (2009), Biochem. Pharmacol., 77, 804-812.
    View publication on PubMed
Search for more literature for 3.4.22.61

Activating Compound

Activating Compound Comment Organism Structure
additional information tumor necrosis factor-related apoptosis-inducing ligand, i.e. Apo2L/TRAIL, is a death messenger that induces apoptosis in many types of human hematological neoplasia including multiple myeloma by inducing activation of caspase-8 and caspase-3. Bortezomib enhances the activating effect on capsase-8 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Bid peptide + H2O Homo sapiens a specific caspase-8 substrate ?
-
 ?
additional information Homo sapiens caspase-8 is involved in apoptosis in multiple myeloma and is the main initiator caspase in the tumor necrosis factor-related apoptosis-inducing pathway overview. c-FLIPL, is the main endogenous regulator of caspase-8 activation, increases with bortezomib treatment but the combination of Apo2L/TRAIL and bortezomib led to a decrease of both FLIP isoforms, regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IM-9 cell express low levels of caspase-8 Homo sapiens
-
multiple myeloma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bid peptide + H2O a specific caspase-8 substrate Homo sapiens ?
-
 ?
additional information caspase-8 is involved in apoptosis in multiple myeloma and is the main initiator caspase in the tumor necrosis factor-related apoptosis-inducing pathway overview. c-FLIPL, is the main endogenous regulator of caspase-8 activation, increases with bortezomib treatment but the combination of Apo2L/TRAIL and bortezomib led to a decrease of both FLIP isoforms, regulation, overview Homo sapiens ?
-
 ?