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Literature summary for 3.4.22.61 extracted from

  • Beurel, E.; Blivet-Van Eggelpoel, M.J.; Kornprobst, M.; Moritz, S.; Delelo, R.; Paye, F.; Housset, C.; Desbois-Mouthon, C.
    Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells (2009), Biochem. Pharmacol., 77, 54-65.
    View publication on PubMed
Search for more literature for 3.4.22.61

Activating Compound

Activating Compound Comment Organism Structure
lithium/SB-415286 two GSK-3 inhibitor, enhance caspase-8 activity in hepatoma cells, but not in healthy hepatocyte, and increase the sensitivity of the cells to tumor necrosis factor-related apoptosis-inducing ligand, i.e. TRAIL, or CH-11, a CD95 agonistic antibody, which leads to increased apoptosis, the agents have no effect alone, mechanism, overview, 1.5-2.1fold activation of CH-11-induced apoptosis at 20 mM LiCl and 0.025 mM SB-415286 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-carbobenzyloxy-VAD-fluoromethyl ketone the pan-caspase inhibitor prevents the sensitizing effects of lithium and SB-415286 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens activation of caspase-8 by glycogen synthase kinase-3 inhibitors can overcome the striking resistance to tumor necrosis factor-related apoptosis-inducing ligand, TRAIL, diplayed by hepatocellular carcinoma cells in contrast to normal heptocytes, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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hepatocyte
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 Homo sapiens
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hepatoma cell
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 Homo sapiens
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HuH-6 cell
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 Homo sapiens
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Mahlavu cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activation of caspase-8 by glycogen synthase kinase-3 inhibitors can overcome the striking resistance to tumor necrosis factor-related apoptosis-inducing ligand, TRAIL, diplayed by hepatocellular carcinoma cells in contrast to normal heptocytes, overview Homo sapiens ?
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 ?