Literature summary for 3.4.22.61 extracted from

Ideo, A.; Hashimoto, K.; Shimada, J.; Kawase, M.; Sakagami, H.
Type of cell death induced by alpha-trifluoromethyl acyloins in oral squamous cell carcinoma (2009), Anticancer Res., 29, 175-181.

Search for more literature for 3.4.22.61

Activating Compound

Activating Compound	Comment	Organism	Structure
actinomycin D	significantly activates caspase-8	Homo sapiens
additional information	alpha-trifluoromethyl acyloins TF2 and TF3, i.e. CF3CH(OH)COPh and CF3CH(OH)COCH2Ph, fail to activate caspase-8 in both HSC-2 and HSC-4 cells during 4-24 hours treatment, however, TF2 and TF3 induce apoptotic cell death in human submandibular gland carcinoma cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HSC-2 cell	a oral squamous cell carcinoma cell line	Homo sapiens	-
HSC-4 cell	a oral squamous cell carcinoma cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ile-Glu-Thr-Asp-4-nitroanilide + H2O	-	Homo sapiens	Ile-Glu-Thr-Asp + 4-nitroaniline	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)