Literature summary for 3.4.22.61 extracted from

Calvaruso, G.; Giuliano, M.; Portanova, P.; De Blasio, A.; Vento, R.; Tesoriere, G.
Bortezomib induces in HepG2 cells IkappaBalpha degradation mediated by caspase-8 (2006), Mol. Cell. Biochem., 287, 13-19.

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	caspase-8 can be involved in the control of IkappaBalpha level. In addition, the activation of caspase-8 can exert, at least in the first phase of treatment with bortezomib, a protective effect in HepG2 cells, favouring the activation of the survival factor NF-kappaB	Homo sapiens	-

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Release 2023.1 (January 2023)