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Literature summary for 3.4.22.61 extracted from

  • Silva, E.M.; Guillermo, L.V.; Ribeiro-Gomes, F.L.; De Meis, J.; Pereira, R.M.; Wu, Z.; Calegari-Silva, T.C.; Seabra, S.H.; Lopes, U.G.; Siegel, R.M.; Dosreis, G.A.; Lopes, M.F.
    Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection (2005), J. Immunol., 174, 6314-6321.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information infection with Trypanosoma cruzi Mus musculus

Application

Application Comment Organism
medicine caspase-8 activity prevents type 2 cytokinine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Cbz-IETD
-
 Mus musculus
viral FLIP
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O89110 viral FLIP transgenic mice
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
 Mus musculus
-
T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IETD-4-nitroanilide + H2O
-
 Mus musculus IETD + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
caspase-8
-
 Mus musculus