Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procaspase-8 is activated through two cleavage events that proceed in a defined order to generate the large and small subunits of the mature protease. The dimerization of procaspase-8 produces enzymatically competent precursors through the stable homophilic interaction of the procaspase-8 protease domain. These dimers are also more susceptible to processing than individual procaspase-8 molecules, which leads to their cross-cleavage. The separation of the large and small subunits renders the region between the large subunit and prodomain susceptible to further cleavage | Homo sapiens |