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Literature summary for 3.4.22.61 extracted from

  • Medema, J.P.; Scaffidi, C.; Kischkel, F.C.; Shevchenko, A.; Mann, M.; Krammer, P.H.; Peter, M.E.
    FLICE is activated by association with the CD95 death-inducing signaling complex (DISC) (1997), EMBO J., 16, 2794-2804.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.61

Activating Compound

Activating Compound Comment Organism Structure
CD95 FLICE is the first in a cascade of ICE-like proteases activated by CD95. This activation requires a functional CD95 disc Mus musculus
CD95 FLICE is the first in a cascade of ICE-like proteases activated by CD95. This activation requires a functional CD95 disc Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus FLICE is the first in a cascade of ICE-like proteases activated by CD95. Active FLICE is released into the cytosol, where it can activate a cascade of ICE-like proteases ?
-
 ?
additional information Homo sapiens FLICE is the first in a cascade of ICE-like proteases activated by CD95. Active FLICE is released into the cytosol, where it can activate a cascade of ICE-like proteases ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BL-60 cell
-
 Homo sapiens
-
H9 cell
-
 Homo sapiens
-
HUT78 cell
-
 Homo sapiens
-
L-929 cell fibroblastoid cell line Mus musculus
-
SKW6.4 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information FLICE is the first in a cascade of ICE-like proteases activated by CD95. Active FLICE is released into the cytosol, where it can activate a cascade of ICE-like proteases Mus musculus ?
-
 ?
additional information FLICE is the first in a cascade of ICE-like proteases activated by CD95. Active FLICE is released into the cytosol, where it can activate a cascade of ICE-like proteases Homo sapiens ?
-
 ?