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Literature summary for 3.4.22.60 extracted from

  • Karki, P.; Dahal, G.R.; Shin, S.Y.; Lee, J.S.; Cho, B.; Park, I.S.
    Efficient cleavage of Bid and procaspase-7 by caspase-2 at lower pH (2008), Protein Pept. Lett., 15, 1044-1049.
    View publication on PubMed
Search for more literature for 3.4.22.60

Activating Compound

Activating Compound Comment Organism Structure
additional information procaspase-7 is physiologically cleaved and activated by caspase-2, optimal conditions, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of procaspase-7 in Escherichia coli strain BL21(DE3) Homo sapiens

Protein Variants

Protein Variants Comment Organism
C186S site-directed mutagenesis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-7 is an important executioner caspase capable of conducting most of apoptotic program in cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-7 is cleaved at Asp198 and Asp206 and activated by caspase-2 Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant procaspase-2 from Escherichia coli strain BL21(DE3) by nickel affinity and ion exchange chromatography to over 95% Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell
-
 Homo sapiens
-
SK-N-BE(2) cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-7 is an important executioner caspase capable of conducting most of apoptotic program in cells Homo sapiens ?
-
 ?
VDVAD-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens VDVAD + 7-amino-4-methylcoumarin
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens