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Literature summary for 3.4.22.60 extracted from

  • Bressenot, A.; Marchal, S.; Bezdetnaya, L.; Garrier, J.; Guillemin, F.; Plenat, F.
    Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma (2009), J. Histochem. Cytochem., 57, 289-300.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
additional information no translocation of active caspase-7 to the nucleus Homo sapiens
-
-
spheroplast spheroids of HT-29 cells Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-7 is involved in apoptosis in cancer cells ?
-
?
poly-ADPribose polymerase 1 + H2O Homo sapiens
-
poly-ADPribose polymerase 1 peptide fragments i.e. c-PARP, frgaments of 24 and 89 kDa ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell
-
Homo sapiens
-
HT-29 cell monolayer cell culture Homo sapiens
-
KB cell monolayer cell culture Homo sapiens
-
MDA-MB-231 cell monolayer cell culture Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
apoptotic activity of active caspase-7, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-7 is involved in apoptosis in cancer cells Homo sapiens ?
-
?
poly-ADPribose polymerase 1 + H2O
-
Homo sapiens poly-ADPribose polymerase 1 peptide fragments i.e. c-PARP, frgaments of 24 and 89 kDa ?
poly-ADPribose polymerase 1 + H2O i.e. PARP-1 Homo sapiens poly-ADPribose polymerase 1 peptide fragments i.e. c-PARP, frgaments of 24 and 89 kDa ?