Application | Comment | Organism |
---|---|---|
medicine | caspase-7 may play a role in ataxin-7 proteolysis and pathology of spinocerebellar ataxia type 7. Inhibition of this protease may be therapeutically important | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ataxin-7 + H2O | Homo sapiens | ataxin-7 is cleaved by caspase-7, cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein. Proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ataxin-7 + H2O | ataxin-7 is cleaved by caspase-7, cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein. Proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis | Homo sapiens | ? | - |
? | |
ataxin-7 + H2O | ataxin-7 is cleaved by caspase-7, cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein | Homo sapiens | ? | - |
? |