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Literature summary for 3.4.22.60 extracted from

  • Song, J.J.; Lee, Y.J.
    Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily (2008), Cell. Signal., 20, 892-906.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mammalian sterile 20-like kinase 1 + H2O Homo sapiens i.e. Mst1. Caspase 7 preferentially activates c-Jun NH2-terminal kinase and p38 preferentially through 40000 Da cleaved forms of Mst1. The 40000 Da form of Mst1 selectively phosphorylates c-Jun NH2-terminal kinase and p38 ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
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 Homo sapiens
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MCF-7 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mammalian sterile 20-like kinase 1 + H2O i.e. Mst1. Caspase 7 preferentially activates c-Jun NH2-terminal kinase and p38 preferentially through 40000 Da cleaved forms of Mst1. The 40000 Da form of Mst1 selectively phosphorylates c-Jun NH2-terminal kinase and p38 Homo sapiens ?
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 ?
mammalian sterile 20-like kinase 1 + H2O i.e. Mst1 Homo sapiens ?
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 ?