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Literature summary for 3.4.22.6 extracted from

  • Dang, L.; Wardlaw, D.; Hukins, D.W.
    Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a laboratory study (2007), BMC Musculoskelet. Disord., 8, 122.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine significantly more nucleus can be removed from a disc using a bilateral rather than a unilateral approach. A unilateral approach using rongeurs alone leads to removal of only about one-third of the nucleus. Rongeurs, followed by chymopapain, lead to removal of significantly more nucleus than when rongeurs are used alone. The most effective method is a bilateral approach using rongeurs followed by chymopapain where about three-quarters of the nucleus can be removed. This approach can create sufficient space for the implant insertion. A brush, which can be inserted through a trocar, assists in the removal of strands of nucleus that are loosened by chymopapain. Experiments are carried out on sheep spines since they are increasingly being used as models for human spines Carica papaya

Organism

Organism UniProt Comment Textmining
Carica papaya
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