Cloned (Comment) | Organism |
---|---|
a His-tagged version (residues 24-293) expressed in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
sitting drop vapour diffusion method | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C163A | active site residue | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0134 | - |
N-acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
0.087 | - |
N-acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin | - |
Homo sapiens | |
0.126 | - |
N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
0.246 | - |
N-acetyl-Val-Glu-His-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
ultracentrifugation | Homo sapiens |
63070 | - |
multi-angle light scattering | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P55212 | - |
- |
Purification (Comment) | Organism |
---|---|
immobilized metal ion affinity chromatography (Ni2+), hydrophobic interaction chromatography, gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-acetyl-Asp-Glu-Val-Asp + 7-amino-4-methylcoumarin | - |
? | |
N-acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | N-acetyl-Asp-Glu-Val-Asp + 7-amino-4-trifluoromethylcoumarin | - |
? | |
N-acetyl-Asp-Leu-Asn-Asp-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-acetyl-Asp-Leu-Asn-Asp + 7-amino-4-methylcoumarin | - |
? | |
N-acetyl-Asp-Val-Val-Asp-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-acetyl-Asp-Val-Val-Asp + 7-amino-4-methylcoumarin | - |
? | |
N-acetyl-Ile-Val-Leu-Asp-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-acetyl-Ile-Val-Leu-Asp + 7-amino-4-methylcoumarin | - |
? | |
N-acetyl-Thr-Glu-Val-Asp-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-acetyl-Thr-Glu-Val-Asp + 7-amino-4-methylcoumarin | - |
? | |
N-acetyl-Val-Glu-His-Asp-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-acetyl-Val-Glu-His-Asp + 7-amino-4-methylcoumarin | - |
? | |
N-acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-acetyl-Val-Glu-Ile-Asp + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 32183.5, mass spectrometry, dimer: 63070, multi-angle light scattering, 58000, ultracentrifugation, after proteolytic maturation each subunit of the active enzyme is a two-chain molecule consisting of the p18 (19668.1 Da, residues 24-179) and p11 (12563.5 Da, residues 194-293), mass spectrometry | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
caspase-6 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
N-acetyl-Ile-Val-Leu-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
3.2 | - |
N-acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin | - |
Homo sapiens | |
3.6 | - |
N-acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
5.5 | - |
N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
6 | - |
N-acetyl-Thr-Glu-Val-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
43 | - |
N-acetyl-Val-Glu-His-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.53 | - |
N-acetyl-Ile-Val-Leu-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
37 | - |
N-acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin | - |
Homo sapiens | |
44 | - |
N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
175 | - |
N-acetyl-Val-Glu-His-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
270 | - |
N-acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens | |
295 | - |
N-acetyl-Thr-Glu-Val-Asp-7-amido-4-methylcoumarin | - |
Homo sapiens |