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Literature summary for 3.4.22.59 extracted from

  • Chan, Y.W.; Chen, Y.; Poon, R.Y.
    Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe (2009), Oncogene, 28, 170-183.
    View publication on PubMed
Search for more literature for 3.4.22.59

Inhibitors

Inhibitors Comment Organism Structure
Ac-VEID-CHO a caspase-6-specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclin B1 + H2O Homo sapiens overriding the G2 DNA damage checkpoint permits precocious entry into mitosis that ultimately leads to mitotic catastrophe, caused by caffeine. Mitotic catastrophe is manifested by an unscheduled activation of CDK1, caspase activation and apoptotic cell death. Cyclin B1 is required for mitotic catastrophe, but is also cleaved into a 35 kDa protein by a caspase-dependent mechanism during the process, overview truncated cyclin B1 + ? expression of the truncated product enhanced cell death ?
lamin A + H2O Homo sapiens specific cleavage by caspase-6 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation through cleavage mainly by caspase-8, partly by caspase-2 and caspase-9 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclin B1 + H2O overriding the G2 DNA damage checkpoint permits precocious entry into mitosis that ultimately leads to mitotic catastrophe, caused by caffeine. Mitotic catastrophe is manifested by an unscheduled activation of CDK1, caspase activation and apoptotic cell death. Cyclin B1 is required for mitotic catastrophe, but is also cleaved into a 35 kDa protein by a caspase-dependent mechanism during the process, overview Homo sapiens truncated cyclin B1 + ? expression of the truncated product enhanced cell death ?
cyclin B1 + H2O cleavage occurs after Asp123 in the motif ILVD123k, mutation of this motif to D123N attenuates the cleavage, cleavage still occurred in the control D160N mutant Homo sapiens truncated cyclin B1 + ? lacking part of the NH2-terminal regulatory domain including the destruction box sequence ?
lamin A + H2O specific cleavage by caspase-6 Homo sapiens ?
-
 ?
poly(ADP-ribose) polymerase + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More cyclin B1 migrates anomalously on SDS-PAGE with 48 kDa predicted size versus 67 kDa experimental size Homo sapiens