Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-actinin-4 + H2O | Homo sapiens | - |
? | - |
? | |
alpha-drebrin + H2O | Homo sapiens | - |
? | - |
? | |
alpha-spinophilin + H2O | Homo sapiens | - |
? | - |
? | |
alpha-tubulin + H2O | Homo sapiens | - |
? | - |
? | |
annexin V + H2O | Homo sapiens | - |
? | - |
? | |
beta-actin + H2O | Homo sapiens | - |
? | - |
? | |
capping protein alpha + H2O | Homo sapiens | - |
? | - |
? | |
cofilin I + H2O | Homo sapiens | - |
? | - |
? | |
eukaryotic elongation factor 1 + H2O | Homo sapiens | - |
? | - |
? | |
ezrin + H2O | Homo sapiens | - |
? | - |
? | |
glial fibrillary acidic protein + H2O | Homo sapiens | - |
? | - |
? | |
glyceraldehyde-3-phosphate dehydrogenase + H2O | Homo sapiens | - |
? | - |
? | |
heat shock protein gp96 precursor + H2O | Homo sapiens | - |
? | - |
? | |
Hsp90alpha + H2O | Homo sapiens | - |
? | - |
? | |
inhibitor-2 of protein phosphatase 2A + H2O | Homo sapiens | - |
? | - |
? | |
inorganic pyrophosphatase + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | caspase-6 activation occurs early in Alzheimer's disease and sometimes precedes the clinical manifestation of the disease in aged individuals. Early and neuritic activation of caspase-6 in Alzheimer disease can disrupt the cytoskeleton network of neurons, resulting in impaired neuronal structure and function in the absence of cell death. Proteomics analysis of caspase-6-mediated cleavage of human neuronal proteins, cleavage site determinations and cleavage specificity, overview | ? | - |
? | |
neurolysin + H2O | Homo sapiens | - |
? | - |
? | |
prolyl endopeptidase + H2O | Homo sapiens | - |
? | - |
? | |
protein 14-3-3epsilon + H2O | Homo sapiens | - |
? | - |
? | |
protein 14-3-3zeta + H2O | Homo sapiens | - |
? | - |
? | |
Rab GDP dissociation factor inhibitor alpha + H2O | Homo sapiens | - |
? | - |
? | |
valosin-containing protein + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | primary neurons, active caspase-6 is localized in neuritic plaques, in neuropil threads, and in neurofibrillary tangles containing neurons that are not morphologically apoptotic in nature | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | Ac-Val-Glu-Ile-Asp + 7-amino-4-trifluoromethylcoumarin | - |
? | |
alpha-actinin-4 + H2O | - |
Homo sapiens | ? | - |
? | |
alpha-drebrin + H2O | - |
Homo sapiens | ? | - |
? | |
alpha-spinophilin + H2O | - |
Homo sapiens | ? | - |
? | |
alpha-tubulin + H2O | - |
Homo sapiens | ? | - |
? | |
annexin V + H2O | - |
Homo sapiens | ? | - |
? | |
beta-actin + H2O | - |
Homo sapiens | ? | - |
? | |
capping protein alpha + H2O | - |
Homo sapiens | ? | - |
? | |
cofilin I + H2O | - |
Homo sapiens | ? | - |
? | |
eukaryotic elongation factor 1 + H2O | - |
Homo sapiens | ? | - |
? | |
ezrin + H2O | - |
Homo sapiens | ? | - |
? | |
glial fibrillary acidic protein + H2O | - |
Homo sapiens | ? | - |
? | |
glyceraldehyde-3-phosphate dehydrogenase + H2O | - |
Homo sapiens | ? | - |
? | |
heat shock protein gp96 precursor + H2O | - |
Homo sapiens | ? | - |
? | |
Hsp90alpha + H2O | - |
Homo sapiens | ? | - |
? | |
inhibitor-2 of protein phosphatase 2A + H2O | - |
Homo sapiens | ? | - |
? | |
inorganic pyrophosphatase + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | caspase-6 activation occurs early in Alzheimer's disease and sometimes precedes the clinical manifestation of the disease in aged individuals. Early and neuritic activation of caspase-6 in Alzheimer disease can disrupt the cytoskeleton network of neurons, resulting in impaired neuronal structure and function in the absence of cell death. Proteomics analysis of caspase-6-mediated cleavage of human neuronal proteins, cleavage site determinations and cleavage specificity, overview | Homo sapiens | ? | - |
? | |
neurolysin + H2O | - |
Homo sapiens | ? | - |
? | |
prolyl endopeptidase + H2O | - |
Homo sapiens | ? | - |
? | |
protein 14-3-3epsilon + H2O | - |
Homo sapiens | ? | - |
? | |
protein 14-3-3zeta + H2O | - |
Homo sapiens | ? | - |
? | |
Rab GDP dissociation factor inhibitor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
valosin-containing protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Csp6 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |