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Literature summary for 3.4.22.59 extracted from

  • Klaiman, G.; Petzke, T.L.; Hammond, J.; Leblanc, A.C.
    Targets of caspase-6 activity in human neurons and Alzheimer disease (2008), Mol. Cell. Proteomics, 7, 1541-1555.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-actinin-4 + H2O Homo sapiens
-
?
-
?
alpha-drebrin + H2O Homo sapiens
-
?
-
?
alpha-spinophilin + H2O Homo sapiens
-
?
-
?
alpha-tubulin + H2O Homo sapiens
-
?
-
?
annexin V + H2O Homo sapiens
-
?
-
?
beta-actin + H2O Homo sapiens
-
?
-
?
capping protein alpha + H2O Homo sapiens
-
?
-
?
cofilin I + H2O Homo sapiens
-
?
-
?
eukaryotic elongation factor 1 + H2O Homo sapiens
-
?
-
?
ezrin + H2O Homo sapiens
-
?
-
?
glial fibrillary acidic protein + H2O Homo sapiens
-
?
-
?
glyceraldehyde-3-phosphate dehydrogenase + H2O Homo sapiens
-
?
-
?
heat shock protein gp96 precursor + H2O Homo sapiens
-
?
-
?
Hsp90alpha + H2O Homo sapiens
-
?
-
?
inhibitor-2 of protein phosphatase 2A + H2O Homo sapiens
-
?
-
?
inorganic pyrophosphatase + H2O Homo sapiens
-
?
-
?
additional information Homo sapiens caspase-6 activation occurs early in Alzheimer's disease and sometimes precedes the clinical manifestation of the disease in aged individuals. Early and neuritic activation of caspase-6 in Alzheimer disease can disrupt the cytoskeleton network of neurons, resulting in impaired neuronal structure and function in the absence of cell death. Proteomics analysis of caspase-6-mediated cleavage of human neuronal proteins, cleavage site determinations and cleavage specificity, overview ?
-
?
neurolysin + H2O Homo sapiens
-
?
-
?
prolyl endopeptidase + H2O Homo sapiens
-
?
-
?
protein 14-3-3epsilon + H2O Homo sapiens
-
?
-
?
protein 14-3-3zeta + H2O Homo sapiens
-
?
-
?
Rab GDP dissociation factor inhibitor alpha + H2O Homo sapiens
-
?
-
?
valosin-containing protein + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron primary neurons, active caspase-6 is localized in neuritic plaques, in neuropil threads, and in neurofibrillary tangles containing neurons that are not morphologically apoptotic in nature Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin + H2O
-
Homo sapiens Ac-Val-Glu-Ile-Asp + 7-amino-4-trifluoromethylcoumarin
-
?
alpha-actinin-4 + H2O
-
Homo sapiens ?
-
?
alpha-drebrin + H2O
-
Homo sapiens ?
-
?
alpha-spinophilin + H2O
-
Homo sapiens ?
-
?
alpha-tubulin + H2O
-
Homo sapiens ?
-
?
annexin V + H2O
-
Homo sapiens ?
-
?
beta-actin + H2O
-
Homo sapiens ?
-
?
capping protein alpha + H2O
-
Homo sapiens ?
-
?
cofilin I + H2O
-
Homo sapiens ?
-
?
eukaryotic elongation factor 1 + H2O
-
Homo sapiens ?
-
?
ezrin + H2O
-
Homo sapiens ?
-
?
glial fibrillary acidic protein + H2O
-
Homo sapiens ?
-
?
glyceraldehyde-3-phosphate dehydrogenase + H2O
-
Homo sapiens ?
-
?
heat shock protein gp96 precursor + H2O
-
Homo sapiens ?
-
?
Hsp90alpha + H2O
-
Homo sapiens ?
-
?
inhibitor-2 of protein phosphatase 2A + H2O
-
Homo sapiens ?
-
?
inorganic pyrophosphatase + H2O
-
Homo sapiens ?
-
?
additional information caspase-6 activation occurs early in Alzheimer's disease and sometimes precedes the clinical manifestation of the disease in aged individuals. Early and neuritic activation of caspase-6 in Alzheimer disease can disrupt the cytoskeleton network of neurons, resulting in impaired neuronal structure and function in the absence of cell death. Proteomics analysis of caspase-6-mediated cleavage of human neuronal proteins, cleavage site determinations and cleavage specificity, overview Homo sapiens ?
-
?
neurolysin + H2O
-
Homo sapiens ?
-
?
prolyl endopeptidase + H2O
-
Homo sapiens ?
-
?
protein 14-3-3epsilon + H2O
-
Homo sapiens ?
-
?
protein 14-3-3zeta + H2O
-
Homo sapiens ?
-
?
Rab GDP dissociation factor inhibitor alpha + H2O
-
Homo sapiens ?
-
?
valosin-containing protein + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Csp6
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens