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Literature summary for 3.4.22.59 extracted from

  • Lee, S.C.; Chan, J.; Clement, M.V.; Pervaiz, S.
    Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop (2006), Proteomics, 6, 2386-2394.
    View publication on PubMed
Search for more literature for 3.4.22.59

Activating Compound

Activating Compound Comment Organism Structure
resveratrol induces caspase-6-dependent cleavage of lamin A Homo sapiens

Application

Application Comment Organism
medicine critical role of caspase-6 and its cleavage of lamin A in apoptotic signaling triggered by resveratrol in the colon carcinoma cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA silencing of caspase-6 expression Homo sapiens
Z-Val-Ala-Asp-fluoromethylketone
-
 Homo sapiens
Z-VEID-fmk
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell variants p53+, p53-, Bax+, Bax- Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lamin A + H2O
-
 Homo sapiens ?
-
 ?
VEID-7-amido-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens VEID + 7-amino-4-trifluoromethylcoumarin
-
 ?