Activating Compound | Comment | Organism | Structure |
---|---|---|---|
adriamycin | increases caspase-6 mRNA levels in HCT116 p53+ and neo cells but not in E6 cells | Homo sapiens | |
etoposide | mild induction of the enzyme in HCT116 p53+ cells | Homo sapiens | |
P53 | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | caspase-6 is upregulated in response to p53 overexpression, induction of caspase-6 expression lowers the cell death threshold in response to apoptotic signals that activate caspase-6, potential mechanism of lowering the death threshold, which could be important for chemosensitization | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DMSO | - |
Homo sapiens | |
VEID-FMK | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DLD-1 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
additional information | p53 up-regulates caspase -6mRNA in H460, H460-neo, H460-E6, HCT16-neo, HCT16-E6, HCT16-P53-, SKBR3, U2OS, M3, HCC1937 and SW13 cell lines, MCF7 cells fail to show induction of caspase 6-mRNA | Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lamin A + H2O | - |
Homo sapiens | ? | - |
? |