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Literature summary for 3.4.22.59 extracted from

  • Guo, H.; Albrecht, S.; Bourdeau, M.; Petzke, T.; Bergeron, C.; LeBlanc, A.C.
    Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease (2004), Am. J. Pathol., 165, 523-531.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.59

Application

Application Comment Organism
medicine caspase-6 is active early in the pathogenesis of Alzheimer´s disease, the enzyme is strongly implicated in human neuronal degeneration and apoptosis, its inhibition may be an efficient treatment Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
inserted into the pIVEX vector Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information active Csp-6 is not present in the nuclei of Alzheimer´s disease neurons Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
additional information present in neurophil threads and neuritic plaques, not in the cerebellum Homo sapiens
-
additional information temporal and frontal cortex Homo sapiens
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neurofibrillary tangle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Tau + H2O cleavage of the microtubule-stabilizing protein by Csp-6 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Csp-6
-
 Homo sapiens