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Literature summary for 3.4.22.57 extracted from

  • Lagrange, B.; Benaoudia, S.; Wallet, P.; Magnotti, F.; Provost, A.; Michal, F.; Martin, A.; Di Lorenzo, F.; Py, B.F.; Molinaro, A.; Henry, T.
    Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11 (2018), Nat. Commun., 9, 242 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens P49662
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function caspase-4 drives inflammasome responses to Francisella novicida infection in human macrophages. Caspase-4 triggers Francisella novicida-mediated, gasdermin D dependent pyroptosis and activates the NLRP3 inflammasome Homo sapiens