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Literature summary for 3.4.22.57 extracted from

  • Kajiwara, Y.; Schiff, T.; Voloudakis, G.; Gama Sosa, M.A.; Elder, G.; Bozdagi, O.; Buxbaum, J.D.
    A critical role for human caspase-4 in endotoxin sensitivity (2014), J. Immunol., 193, 335-343.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine regulation of the expression, activation, or activity of caspase-4 represents targets for systemic inflammatory response syndrome, sepsis, septic shock, and related disorders Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procaspase-1 + H2O Homo sapiens
-
 caspase-1 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte-derived macrophage
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procaspase-1 + H2O
-
 Homo sapiens caspase-1 + ?
-
 ?

Synonyms

Synonyms Comment Organism
CASP4
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function caspase-4 is involved in endotoxin sensitivity. Caspase-4 can support activation of caspase-1 and secretion of interleukin-1beta and interleukin-18 in response to priming signals (LPS or Pam3CSK4) alone, without the need for second signals to stimulate the assembly of the inflammasome Homo sapiens