Literature summary for 3.4.22.56 extracted from

Van Kersavond, T.; Konopatzki, R.; Chakrabarty, S.; Blank-Landeshammer, B.; Sickmann, A.; Verhelst, S.H.L.
Short peptides with uncleavable peptide bond mimetics as photoactivatable caspase-3 inhibitors (2019), Molecules, 24, E206 .

Search for more literature for 3.4.22.56

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Mammalia

Inhibitors

Inhibitors	Comment	Organism	Structure
acetyl-Asp-Glu-Val-Asp(psi)(CH2NH)-Ala-NH2	no ihibition without irradiation, complete inhibition when the sample is irradiated	Mammalia
hexynoyl-Asp-Glu-Val-Asp(psi)(CH2NH)-Ala-Bpa-NH2	no ihibition without irradiation, complete inhibition when the sample is irradiated	Mammalia
hexynoyl-Asp-Glu-Val-Asp(psi)(CH2NH)-Ala-NH2	no ihibition without irradiation, complete inhibition when the sample is irradiated	Mammalia
hexynoyl-Asp-Glu-Val-Asp(psi)(CH2NH)-Ala-photoLeu-NH2	no ihibition without irradiation, complete inhibition when the sample is irradiated	Mammalia
hexynoyl-Asp-Glu-Val-Asp(triazolo)-Ala-Bpa-Gly-NH2	weak inhibition	Mammalia
hexynoyl-Bpa-Asp-Glu-Val-Asp(psi)(CH2NH)-Ala-NH2	no ihibition without irradiation, complete inhibition when the sample is irradiated	Mammalia
hexynoyl-photoLeu-Asp-Glu-Val-Asp(psi)(CH2NH)-Ala-NH2	no ihibition without irradiation, complete inhibition when the sample is irradiated	Mammalia
additional information	molecules with psi(CH2NH) or triazole uncleavable peptide bond do not show any inhibition of caspase activity without irradiation. When the samples are irradiated, the psi(CH2NH) peptides with benzophenone or diazirine photocrosslinkers show complete inhibition	Mammalia

Organism

Organism	UniProt	Comment	Textmining
Mammalia	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ac-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin + H2O	-	Mammalia	Ac-Asp-Glu-Val-Asp + 7-amino-4-methylcoumarin	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mammalia

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Mammalia

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Release 2023.1 (January 2023)