Literature summary for 3.4.22.56 extracted from

Tavari, M.; Malan, S.; Joubert, J.
Design, synthesis, biological evaluation and docking studies of sulfonyl isatin derivatives as monoamine oxidase and caspase-3 inhibitors (2016), MedChemComm, 7, 1628-1639 .

No PubMed abstract available

Search for more literature for 3.4.22.56

Inhibitors

Inhibitors	Comment	Organism	Structure
N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone	-	Homo sapiens
N-[(2-fluorophenyl)methyl]-N-methyl-2,3-dioxo-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide	-	Homo sapiens
N-[(2-fluorophenyl)methyl]-N-methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonamide	-	Homo sapiens
N-[(3-fluorophenyl)methyl]-N-methyl-2,3-dioxo-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide	-	Homo sapiens
N-[(3-fluorophenyl)methyl]-N-methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonamide	-	Homo sapiens
N-[(4-fluorophenyl)methyl]-N-methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonamide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P42574	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DEVD-amido-4-trifluoromethylcoumarin + H2O	-	Homo sapiens	DEVD + amino-4-trifluoromethylcoumarin	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.02508	-	37°C, pH 7.6	Homo sapiens	N-[(3-fluorophenyl)methyl]-N-methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonamide
0.02926	-	37°C, pH 7.4	Homo sapiens	N-[(4-fluorophenyl)methyl]-N-methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonamide
0.04	-	pH 7.4, 37°C	Homo sapiens	N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
0.04474	-	37°C, pH 7.4	Homo sapiens	N-[(2-fluorophenyl)methyl]-N-methyl-2,3-dioxo-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide
0.05149	-	37°C, pH 7.4	Homo sapiens	N-[(3-fluorophenyl)methyl]-N-methyl-2,3-dioxo-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide
0.06096	-	37°C, pH 7.4	Homo sapiens	N-[(2-fluorophenyl)methyl]-N-methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonamide

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Release 2023.1 (January 2023)