Literature summary for 3.4.22.56 extracted from

Lin, B.; Zhu, M.; Wang, W.; Li, W.; Dong, X.; Chen, Y.; Lu, Y.; Guo, J.; Li, M.
Structural basis for alpha fetoprotein-mediated inhibition of caspase-3 activity in hepatocellular carcinoma cells (2017), Int. J. Cancer, 141, 1413-1421 .

Search for more literature for 3.4.22.56

Cloned(Commentary)

Cloned (Comment)	Organism
the full-length caspase-3 gene containing an N-terminal 6His-tag is expressed in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-fetoprotein	interacts with caspase-3 through precise amino acids, namely loop-4 residues Glu-248, Asp-253 and His-257. alpha-Fetoprotein plays a critical role in the inhibition of the apoptotic signal transduction that mediated by caspase-3	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P42574	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatoma cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)