Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.56 extracted from

  • Bagchi, P.; Dutta, D.; Chattopadhyay, S.; Mukherjee, A.; Halder, U.C.; Sarkar, S.; Kobayashi, N.; Komoto, S.; Taniguchi, K.; Chawla-Sarkar, M.
    Rotavirus nonstructural protein 1 suppresses virus-induced cellular apoptosis to acilitate viral growth by activating the cell survival pathways during early stages of infection (2010), J. Virol., 84, 6834-6845.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.56

Inhibitors

Inhibitors Comment Organism Structure
DEVD-fluoromethylketone
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-29 cell
-
 Homo sapiens
-
MA-104 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DEVD-7-amido-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens DEVD + 7-amino-4-trifluoromethylcoumarin
-
 ?

Expression

Organism Comment Expression
Homo sapiens in contrast to low XIAP expression, the A5-16 strain shows enhanced cleavage of caspase-3 as early as 8 hours post infection with a 6-8fold increase by 12 hours post infection. There is a significant increase in caspase-3 activity (2-3fold) at an early stage of infection (4-8 hours post infection) in mutant strain A5-16-infected cells compared to the A5-13 infection. At 12-18 hours post infection, the caspase-3 activity in A5-13-infected cells increases significantly relative to mock-infected controls up