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Literature summary for 3.4.22.56 extracted from

  • Coiras, M.; Lopez-Huertas, M.R.; Mateos, E.; Alcami, J.
    Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IkappaBalpha and enhances HIV-1 replication in human T lymphocytes (2008), Retrovirology, 5, 109.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Ac-DMQD-CHO
-
Homo sapiens
N-carbobenzyloxy-VAD-fluoromethyl ketone
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
p65/RelA + H2O Homo sapiens caspase-3-mediated carboxy-terminal fragment of p65/RelA production, cells producing this truncated p65/RelA do not undergo apoptosis but show a high viability, in spite of caspase-3 activation, overview. The substrate translocate to the nucleus, associates with NF-kappaB1/p50 and IkappaBalpha, but cannot bind -kappaB consensus sites ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-3 is expressed as an inactive 32 kDa precursor from which the p20 and p11 subunits are proteolytically generated during onset of apoptosis Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
-
T-lymphocyte activated, from human peripheral blood Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p65/RelA + H2O caspase-3-mediated carboxy-terminal fragment of p65/RelA production, cells producing this truncated p65/RelA do not undergo apoptosis but show a high viability, in spite of caspase-3 activation, overview. The substrate translocate to the nucleus, associates with NF-kappaB1/p50 and IkappaBalpha, but cannot bind -kappaB consensus sites Homo sapiens ?
-
?
p65/RelA + H2O caspase-3-mediated carboxy-terminal fragment of p65/RelA production, no activity with substrate mutants V91L/D94E, D97E, and D94E/D97E Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More caspase-3 is expressed as an inactive 32 kDa precursor from which the p20 and p11 subunits are proteolytically generated during onset of apoptosis Homo sapiens