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Literature summary for 3.4.22.56 extracted from

  • Stegh, A.H.; Kesari, S.; Mahoney, J.E.; Jenq, H.T.; Forloney, K.L.; Protopopov, A.; Louis, D.N.; Chin, L.; DePinho, R.A.
    Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma (2008), Proc. Natl. Acad. Sci. USA, 105, 10703-10708.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information alphaB-crystallin knockdown sensitizes Bcl2L12-expressing astrocytes toward apoptosis in association with increased effector caspase activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Bcl2-Like12 is a nuclear and cytoplasmic oncoprotein that inhibits caspase-3 and apoptosis, mechanism, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-3 is involved in apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procapase-3 is cleaved to active caspase-3 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary Homo sapiens
-
glioblastoma multiforme cell overexpressing Bcl2-Like12 nuclear and cytoplasmic oncoprotein Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-3 is involved in apoptosis Homo sapiens ?
-
 ?