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Literature summary for 3.4.22.56 extracted from

  • Du, Y.; Li, C.; Hu, W.W.; Song, Y.J.; Zhang, G.Y.
    Neuroprotection of preconditioning against ischemic brain injury in rat hippocampus through inhibition of the assembly of GluR6-PSD95-mixed lineage kinase 3 signaling module via nuclear and non-nuclear pathways (2009), Neuroscience, 161, 370-380.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
cytochrome c induces caspas-3 activation Homo sapiens
additional information ischemic/reperfusion in brain leads to increased release of cytochrome c from mitochondria and activation of caspase-3, ischemic preconditioning and ischemic tolerance can diminish the activation of caspase-3, overview Homo sapiens

Application

Application Comment Organism
diagnostics active caspase-3 immunostaining is considered as a highly reliable and specific morphological marker of early apoptosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information ischemic/reperfusion in brain leads to increased release of cytochrome c from mitochondria and activation of caspase-3, ischemic preconditioning with 6,7,8,9-tetrahydro-5-nitro-1 H-benz[g]indole-2,3-dione-3-oxime, i.e. NS102, and ischemic tolerance can diminish the activation of caspase-3, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-3 activation results in apoptosis, ischemic/reperfusion in brain leads to increased release of cytochrome c from mitochondria and activation of caspase-3, ischemic preconditioning and ischemic tolerance can diminish the activation of caspase-3, regulation, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-3 activation results in apoptosis, ischemic/reperfusion in brain leads to increased release of cytochrome c from mitochondria and activation of caspase-3, ischemic preconditioning and ischemic tolerance can diminish the activation of caspase-3, regulation, overview Homo sapiens ?
-
 ?