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Literature summary for 3.4.22.56 extracted from
- Inhibition of nNOS reduces ischemic cell death through down-regulating calpain and caspase-3 after experimental stroke (2009), Neurochem. Int., 54, 339-346.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | caspase-3 is involved in the ischemic brain injury during experimental stroke. In vitro nitric oxide regulates calpain and caspase-3 activation, and in vivo neuronal nitric oxide synthase, calpain and caspase-3 participate in the ischemic brain injury, inhibition of the neuronal nitric oxide synthase by 7-nitroindazole leads to downregulation of caspase-3, mechanism, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | caspase-3 is increased in ischemic brain, in penumbra and core | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DEVD-7-amido-4-fluoromethylcoumarin + H2O | - |
Rattus norvegicus | DEVD + 7-amino-4-fluoromethylcoumarin | - |
? | |
| additional information | caspase-3 is involved in the ischemic brain injury during experimental stroke. In vitro nitric oxide regulates calpain and caspase-3 activation, and in vivo neuronal nitric oxide synthase, calpain and caspase-3 participate in the ischemic brain injury, inhibition of the neuronal nitric oxide synthase by 7-nitroindazole leads to downregulation of caspase-3, mechanism, overview | Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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