Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | thiorphan, a specific NEP/CD10 inhibitor, causes downregulation of procaspase-3 mRNA levels and suppression of caspase-3 activity in a neurokinin-1 receptor-dependent manner. The effect is abrogated by the NK1R antagonist (S)1-{2-[3(3-4-dichlorophenyl)-1-(3-iso-propoxyphenylacetyl)-piperidine-3-yl]ethyl}-4-pheny-1-azoniabicyclo[2.2.2]octane, chloride, i.e. SR140333, overview | Rattus norvegicus | |
survivin | inhibits processing of procaspase-3 and specifically binds the active form of caspase-3 through a baculovirus inhibitor of apoptosis, IAP, repeat domain | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | caspase-3 is involved in apoptosis in thymocytes, enzyme inhibition increases cell survival, regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | caspase-3 is activated from procaspase-3 by cleavage | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thymocyte | constitutive caspase-3 activity | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-3 is involved in apoptosis in thymocytes, enzyme inhibition increases cell survival, regulation, overview | Rattus norvegicus | ? | - |
? |