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Literature summary for 3.4.22.56 extracted from

  • Hsiao, Y.P.; Huang, H.L.; Lai, W.W.; Chung, J.G.; Yang, J.H.
    Antiproliferative effects of lactic acid via the induction of apoptosis and cell cycle arrest in a human keratinocyte cell line (HaCaT) (2009), J. Dermatol. Sci., 54, 175-184.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
Lactic acid induces the activation of caspase-3 in keratinocytes, the activation can be inhibited by N-carbobenzyloxy-VAD-fluoromethyl ketone, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-carbobenzyloxy-VAD-fluoromethyl ketone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens external lactic acid induces apoptosis via the caspase-dependent pathway activating caspase-3, -8, and -9, and the caspase-independent pathway causing increased expressions of AIF and EndoG, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information external lactic acid induces apoptosis via the caspase-dependent pathway activating caspase-3, -8, and -9, and the caspase-independent pathway causing increased expressions of AIF and EndoG, overview Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens