Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.56 extracted from

  • Casely-Hayford, M.A.; Nicholas, S.A.; Sumbayev, V.V.
    Azinomycin epoxide induces activation of apoptosis signal-regulating kinase 1 (ASK1) and caspase 3 in a HIF-1alpha-independent manner in human leukaemia myeloid macrophages (2009), Eur. J. Pharmacol., 602, 262-267.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
azinomycin epoxide i.e. (2S,3S)-benzyl 3,4-epoxy-2-(3-methoxy-5-methyl-1-naphthoyloxy)-3-methylbutanamide, leads to activation and apoptosis in THP-1 cells in a p53-independent manner, while human apoptosis signal-regulating kinase 1, ASK1, is highly required for caspase-3 activation by (2S,3S)-benzyl 3,4-epoxy-2-(3-methoxy-5-methyl-1-naphthoyloxy)-3-methylbutanamide, transient expression of the dominant-negative human ASK1 with kinase-dead domain in THP-1 cells abolishes the caspase-3 activating effect of azinomycin epoxide, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens azinomycin epoxide leads to activation and apoptosis in THP-1 cells in a p53-independent manner ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage leukaemia myeloid Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
additional information azinomycin epoxide leads to activation and apoptosis in THP-1 cells in a p53-independent manner Homo sapiens ?
-
 ?