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Literature summary for 3.4.22.56 extracted from

  • Danielisova, V.; Gottlieb, M.; Nemethova, M.; Krav?ukova, P.; Domorakova, I.; Mechirova, E.; Burda, J.
    Bradykinin postconditioning protects pyramidal CA1 neurons against delayed neuronal death in rat hippocampus (2009), Cell. Mol. Neurobiol., 29, 871-878.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
cytochrome c forebrain ischemia causes release of cytochrome c from mitochondria and translocation to the nucleus, which induces caspase-3 activation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
bradykinin prevents caspase-3 activation in neurons Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus increased cytosolic cytochrome c and subsequently caspase-3 activation are additional signs of neuronal death via the mitochondrial pathway. Bradykinin administration significantly attenuates ischemia-induced neuronal death, and also suppresses the release of MnSOD, and cytochrome c, and prevents caspase-3 activation ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
forebrain
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 Rattus norvegicus
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hippocampus CA1 region Rattus norvegicus
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neuron pyramidal CA1 Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 caspase-3 activity in healthy hippocampus, hippocampus after 8 min of transient forebrain ischemia, and after 3 days of reperfusion, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Asp-Glu-Val-Asp-4-nitroanilide + H2O
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 Rattus norvegicus Asp-Glu-Val-Asp + 4-nitroaniline
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 ?
additional information increased cytosolic cytochrome c and subsequently caspase-3 activation are additional signs of neuronal death via the mitochondrial pathway. Bradykinin administration significantly attenuates ischemia-induced neuronal death, and also suppresses the release of MnSOD, and cytochrome c, and prevents caspase-3 activation Rattus norvegicus ?
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 ?