Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-methoxyestradiol | increases the enzyme activity 2fold at 100 nM | Homo sapiens | |
doxorubicin | augments caspase-3 activity | Homo sapiens | |
doxorubicin/2-methoxyestradiol | both in combination activate the enzyme 27fold | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DEVD-fluoromethyl ketone | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | caspase-3 is playing a central role in the execution of apoptosis, its activation induces Dox resistance, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | a breast cancer Dox resistant MCF-7/Dox cell line | Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DEVD-7-amido-4-fluoromethylcoumarin + H2O | - |
Homo sapiens | DEVD + 7-amino-4-fluoromethylcoumarin | - |
? | |
additional information | caspase-3 is playing a central role in the execution of apoptosis, its activation induces Dox resistance, mechanism, overview | Homo sapiens | ? | - |
? |