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Literature summary for 3.4.22.56 extracted from

  • Cheah, Y.H.; Nordin, F.J.; Tee, T.T.; Azimahtol, H.L.; Abdullah, N.R.; Ismail, Z.
    Antiproliferative property and apoptotic effect of xanthorrhizol on MDA-MB-231 breast cancer cells (2009), Anticancer Res., 28, 3677-3689.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
xanthorrhizol a natural sesquiterpenoid compound isolated from the rhizome of Curcuma xanthorrhizza, modulates MDA-MB-231 cell apoptosis through the mitochondria-mediated pathway subsequent to the disruption of mitochondrial transmembrane potential, release of cytochrome c, activation of caspase-3 and caspase-9, and the modulation of PARP-1 protein, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information xanthorrhizol does not affect caspase-8 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-3, an effector caspase, is involved in MDA-MB-231 apoptotic cell death, overview. Caspase-3 is activated when procaspase-3 is cleaved subsequently from the recruitment of Fas associated protein with death domain, FADD, to the death-effector domain site of procaspase-8 during the oligomerization of death receptor and its ligand ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-8 is activated when procaspase-8 is cleaved subsequently from the recruitment of Fas associated protein with death domain, FADD, to the death-effector domain site of procaspase-8 during the oligomerization of death receptor and its ligand Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
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MDA-MB-231 cell invasive breast cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ile-Glu-Thr-Asp-4-nitroanilide + H2O
-
 Homo sapiens Ile-Glu-Thr-Asp + 4-nitroaniline
-
 ?
additional information caspase-3, an effector caspase, is involved in MDA-MB-231 apoptotic cell death, overview. Caspase-3 is activated when procaspase-3 is cleaved subsequently from the recruitment of Fas associated protein with death domain, FADD, to the death-effector domain site of procaspase-8 during the oligomerization of death receptor and its ligand Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens