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Literature summary for 3.4.22.56 extracted from

  • Johnke, R.M.; Smith, E.S.; Cariveau, M.J.; Evans, M.J.; Kilburn, J.M.; Bakken, N.T.; Nangami, G.N.
    Radioprotection of murine gastrointestinal epithelium by interleukin-1alpha involves down-regulation of the apoptotic response (2009), Anticancer Res., 28, 3601-3607.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-3 activation and apoptosis are increased under irradiation stress, but interleukin-1 does prevent it when used in pretreatment, interleukin-1beta pretreatment causes reduced caspase-3 activation, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information interleukin-1 downregulates caspase-3 expression and reduces apoptsis within the gastrointestinal crypts Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-3 is an effector caspase lying downstream from both intrinsic apoptotic pathway mediators and extrinsic apoptotic pathway mediators ?
-
 ?
additional information Mus musculus C57BL/6 caspase-3 is an effector caspase lying downstream from both intrinsic apoptotic pathway mediators and extrinsic apoptotic pathway mediators ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 C57BL/6 mice
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Mus musculus C57BL/6
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 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
goblet cell main localization in the jejunum Mus musculus
-
jejunum immunohistochemical determination of active caspases Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-3 is an effector caspase lying downstream from both intrinsic apoptotic pathway mediators and extrinsic apoptotic pathway mediators Mus musculus ?
-
 ?
additional information caspase-3 is an effector caspase lying downstream from both intrinsic apoptotic pathway mediators and extrinsic apoptotic pathway mediators Mus musculus C57BL/6 ?
-
 ?