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Literature summary for 3.4.22.56 extracted from

  • Goode, D.R.; Sharma, A.K.; Hergenrother, P.J.
    Using peptidic inhibitors to systematically probe the S1 site of caspase-3 and caspase-7 (2005), Org. Lett., 7, 3529-3532.
    View publication on PubMed
Search for more literature for 3.4.22.56

Inhibitors

Inhibitors Comment Organism Structure
(4S,7S,10S,13S)-7-(2-carboxyethyl)-4-(carboxymethyl)-13-(cyclobutylcarbonyl)-10-(1-methylethyl)-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid non-preferred name, comparison with inhibition of caspase-7 Homo sapiens
Acetyl-Asp-Glu-Val-Asp-aldehyde
-
 Homo sapiens
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-phenylpropyl]-L-valinamide comparison with inhibition of caspase-7 Homo sapiens
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxo-4-phenylbutyl]-L-valinamide comparison with inhibition of caspase-7 Homo sapiens
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxoheptyl]-L-valinamide comparison with inhibition of caspase-7 Homo sapiens
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxooctyl]-L-valinamide comparison with inhibition of caspase-7 Homo sapiens
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-4-(2,5-dimethylphenyl)-2-oxobutyl]-L-valinamide comparison with inhibition of caspase-7 Homo sapiens
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-4-(3-methylphenyl)-2-oxobutyl]-L-valinamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant enzyme
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
 N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-4-(2,5-dimethylphenyl)-2-oxobutyl]-L-valinamide
-
 Homo sapiens
0.0007
-
 N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-4-(3-methylphenyl)-2-oxobutyl]-L-valinamide
-
 Homo sapiens
0.0011
-
 N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxoheptyl]-L-valinamide
-
 Homo sapiens
0.0013
-
 N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxooctyl]-L-valinamide
-
 Homo sapiens
0.0015
-
 N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-phenylpropyl]-L-valinamide
-
 Homo sapiens
0.0021
-
 (4S,7S,10S,13S)-7-(2-carboxyethyl)-4-(carboxymethyl)-13-(cyclobutylcarbonyl)-10-(1-methylethyl)-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
-
 Homo sapiens
0.0035
-
 N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxo-4-phenylbutyl]-L-valinamide
-
 Homo sapiens
0.0058
-
 Acetyl-Asp-Glu-Val-Asp-aldehyde
-
 Homo sapiens